ABSTRACT
Objective To explore the levels and clinical significance of visfatin and VE-cadherin in the serum of children with Kawasaki diseases (KD).Methods Serum levels of visfatin and VE-cadherin were measured in 90 children with KD and 30 healthy children (control group) by ELISA,the outcome was estimated in combination with clinical symptoms.Results The serum levels of visfatin [ (32.35 ± 4.82)μg/L ] and VE-cadherin[ (5.03 ± 1.06)mg/L] in children with KD were obviously higher than those in control group[ (16.83 ±4.36) μg/L,(2.86 ± 1.02) mg/L] (t = 15.23,12.47,P ＜0.01).The serum levels of visfatin[ (36.61 ±5.22) μg/L] and VE-cadherin [ (6.14 ± 1.23) mg/L] in children with KD and CAL were obviously higher than children of KD without CAL[ (28.16 ± 4.67)g/L,(4.02 ± 1.01)mg/L] (t =8.38,7.16,P ＜0.01).In children with KD,the serum levels of visfatin and VE-cadherin were significantly correlated (r = 0.65,P ＜ 0.05).Conclusions Serum levels of visfatin and VE-cadherin increased in the acute phase of KD,and it was significantly increased in those KD children with CAL.Visfatin and VE-cadherin may be used as an important serological indicator of KD with CAL.